CD82 hypomethylation is essential for tuberculosis pathogenesis via regulation of RUNX1-Rab5/22
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چکیده
منابع مشابه
Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma.
Previous studies have shown that Th2 cytokine genes on mouse chromosome 11 are coordinately regulated by the Th2 locus control region (LCR). To examine the in vivo function of Th2 LCR, we generated CD4-specific Th2 LCR-deficient (cLCR KO) mice using Cre-LoxP recombination. The number of CD4 T cells in the cLCR KO mouse was comparable to that in wild-type mice. The expression of Th2 cytokines wa...
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Chaperone and protease systems play essential roles in cellular homeostasis and have vital functions in controlling the abundance of specific cellular proteins involved in processes such as transcription, replication, metabolism and virulence. Bacteria have evolved accurate regulatory systems to control the expression and function of chaperones and potentially destructive proteases. Here, we ha...
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Annual influenza epidemics and occasional pandemics pose a severe threat to human health. Host cell factors required for viral spread but not for cellular survival are attractive targets for novel approaches to antiviral intervention. The cleavage activation of the influenza virus hemagglutinin (HA) by host cell proteases is essential for viral infectivity. However, it is unknown which protease...
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ژورنال
عنوان ژورنال: Experimental & Molecular Medicine
سال: 2018
ISSN: 1226-3613,2092-6413
DOI: 10.1038/s12276-018-0091-4